Stimulator of Interferon Genes (STING) Triggers Adipocyte Autophagy

Innate immune signaling in adipocytes affects systemic metabolism. Cytosolic nucleic acid sensing has been recently shown to stimulate thermogenic adipocyte differentiation and protect from obesity; however, DNA efflux mitochondria is a potential proinflammatory signal that causes adipose tissue dysfunction insulin resistance. activates the stimulator of interferon response genes (STING), key transducer which triggers type I (IFN-I) expression; hence, STING activation expected induce IFN-I dysfunction. However, we show herein mouse had diminished stimulation by 2′3′-cyclic-GMP-AMP (cGAMP). We also cGAMP triggered autophagy murine human adipocytes. In turn, inhibition reduced autophagosome number, compromised mitochondrial network caused inflammation fat accumulation hence stimulates process removes damaged mitochondria, thereby protecting an excessive efflux. summary, appears limit promoting mitophagy under non-obesogenic conditions.